Experimental/Clinical Studies
Trypsin:Chymotrypsin as Compared to Serratiopeptidase and Trypsin:Bromelain:Rutoside in Wound Manage
Advances in Therapy, volume 34, pages 180–198 (2017)
Conclusion:
TC provides a better resolution of symptoms of inflammation after orthopedic surgery as compared to S and TBR, thus facilitating better wound healing. Further studies are warranted to confirm the findings.
The Role of Trypsin:Chymotrypsin in Tissue Repair
Advances in Therapy volume 35, pages 31–42 (2018)
Conclusion:
Owing to anti-inflammatory, anti-edematous, fibrinolytic, anti-infective, and analgesic effects, trypsin:chymotrypsin oral combination has emerged as a promising treatment to facilitate healing of traumatic injuries. It promotes speedier recovery and better resolution of inflammatory signs and symptoms due to tissue injury than several of the other existing enzyme preparations. It also demonstrates analgesic effects and reduces pain associated with healing. The efficacy and safety of trypsin:chymotrypsin in accidental injuries, surgical and orthopedic injuries, burns, and sciatica has been corroborated by a substantial and largely consistent body of evidence from clinical trials.
The Effect of Trypsin-Chymotrypsin on Postoperative Pain after Single Visit Endodontic Treatment: A
Journal of Endodontics, Volume 49, Issue 3, March 2023, Pages 240-247
Conclusion:
Trypsin-chymotrypsin exhibits comparable efficacy to nonsteroidal anti-inflammatory drugs. No synergistic effects occur when the 2 are used in combination. This is the first randomized controlled trial to assess the effects of proteolytic enzymes on postendodontic pain.
Effectiveness Of Trypsin - Chymotrypsin as an Anti Inflammatory in Maxillofacial Trauma - A Double B
International Journal of Dentistry and Oral Science (IJDOS) ISSN: 2377-8075
Conclusion:
Owing to anti-inflammatory, anti-oedematous, fibrinolytic, anti-infective, and analgesic effects, trypsin: chymotrypsin oral combination has emerged as a promising treatment to facilitate healing of traumatic injuries. Trypsin chymotrypsin combination always showed a significant reduction in swelling and pain postoperatively.
Proteases and tissue repair: peri operative role of chymotrypsin: trypsin in surgical patients
International Surgery Journal, Kondreddy S et al. Int Surg J. 2019 Jan;6(1):283-286
Conclusion:
From the current study, it is thus concluded that trypsin:chymotrypsin prophylaxis pre-operatively and post-operative treatment in surgical patients hastens the healing process and significantly reduces the recovery time